Ritlecitinib in Patients With Keloids or Those Undergoing Keloidectomy
Keloids are common, benign cutaneous overgrowths that manifest clinically as raised, hypertrophic, often hyperpigmented lesions which are formed in response to dermal injury or idiopathic stimuli. Although keloids are a common disease, it's exact incidence and prevalenc...
Age: 18 years - 66+
Gender: All
Intratumoral and Systemic Hiltonol® (Poly-ICLC) in Prostate Cancer Patients on Active Surveillance
This is a partially blinded randomized controlled phase II pilot study comparing Poly-ICLC (Hiltonol®) treatment vs no treatment, for prostate cancer participants on active surveillance.
Age: 18 years - 66+
Gender: Male
Bimekizumab in Plaque Psoriasis
The purpose of this research study is to evaluate the effectiveness and safety of bimekizumab
in individuals with moderate-to-severe psoriasis who have failed similar therapies.
Bimekizumab improves psoriasis by suppressing a type of substance found in bodies called...
Age: 18 years - 66+
Gender: All
Erector Spinae Plane Block With Bupivacaine for Medical Thoracoscopy
PlAcebo versus erector spINae pLane block for mEdical ThoracoScopy Study (PAINLESS). This is
a prospective triple-blind, randomized controlled trial that evaluates the efficacy of
erector spinae plane block (ESPB) with Bupivacaine in reducing pain after medical
th...
Age: 18 years - 66+
Gender: All
Behavioral and Cognitive Predictors of Persistent Pain and Opioid Misuse in Chronic Pain
Chronic lower back pain (CLBP) affects approximately 20% of the global population. The study objective is to determine if impulsivity, inhibitory control, drug choice, and/or cognitive distortions predict opioid misuse and disability in patients with chronic pain. This ...
Age: 18 years - 66+
Gender: All
Study to Evaluate the Efficacy, Safety, and Tolerability of an Anti-MTBR Tau Monoclonal Antibody (BMS-986446) in Participants With Early Alzheimer's Disease
The purpose of this study is to assess the effectiveness, safety, and tolerability of
BMS-986446 an Anti-MTBR Tau Monoclonal Antibody in participants with Early Alzheimer's
Disease.
Age: 50 - 80 years
Gender: All
Social Determinants of Health, Medication Use, and Quality of Life in Inflammatory Bowel Disease
Optimizing health related-quality of life (HRQoL) for patients with inflammatory bowel
disease (IBD), who often experience a relapsing disease course, is an essential component of
care. Improving IBD disease control is linked to increased health-related quality of l...
Age: 18 years - 66+
Gender: All
Transcutaneous Electrical Nerve Stimulation (TENS) for IUD Insertion Pain
This study is a double-blind, randomized, placebo-controlled trial to evaluate the use of high frequency TENS for pain control during IUD insertion. Transcutaneous electrical nerve stimulation (TENS) is a relatively low-cost, low-risk, non-pharmacologic intervention for...
Age: 18 years - 66+
Gender: All
Impact of Intraoperative Cell Salvage
Patients presenting for elective cesarean section will be screened for pre-procedural anemia. If the potential subject meets the selection criteria they will be presented with the option of participating in the study. Once consented the participant is randomized by enve...
Age: 18 years - 66+
Gender: Female
Tier - Palliative Care For Patients With Advanced Heart Failure or Cancer
TIER-PC is an adaptive model of delivering palliative care that provides the right level of
care to the right patients at the right time. It represents an adaption of the Mount Sinai
PALLIATIVE CARE AT HOME (PC@H) program, which delivers home-based palliative care. ...
Age: 18 years - 66+
Gender: All
Neural Circuit Effects of Ketamine in Depression
This project is designed to examine the role of the subgenual anterior cingulate cortex (sgACC) in anhedonia and anxiety in humans with depression, as well as the acute and sustained effects of ketamine on agACC activation and depression symptoms.
Age: 18 - 65 years
Gender: All
A Multicenter Multinational Observational Study of Children With Hypochondroplasia
This study will assess growth over time and the clinical course of HCH in children by
collecting growth measurements and other variables of interest.
Age: Birth - 15 years
Gender: All
Cannabidiol for Opioid Addiction
The long-term goal of the project is to determine whether cannabidiol (CBD) can reduce craving and relapse in individuals with opioid use disorder (OUD). The first phase of our project was an open cross-over design study in healthy individuals to confirm the safety and ...
Age: 18 - 65 years
Gender: All
First In Human Dose Escalation Study Evaluating Safety of TheraSphere Prostate Cancer (PCa) Device
The VOYAGER Study is an interventional, non-randomized, single-arm, dose escalation trial
with the goal of determining the safety of TheraSphere PCa device in patients with clinically
localized prostate cancer across US-based centers.
Age: 50 years - 66+
Gender: Male
Evaluating the Efficacy of the eNav Toolkit to Improve Colorectal Cancer Screening
The purpose of this research study is to evaluate the efficacy of a digital navigation tool,
called the eNav to improve colorectal cancer screening uptake among patients treated at
federally qualified health centers (FQHC)s. The digital navigation tool includes a we...
Age: 45 - 75 years
Gender: All
Laminar LAAX Pivotal IDE Study
The goal of this clinical trial is to compare the Laminar Left Atrial Appendage Closure
System to commercially available left atrial appendage closure devices. This procedure is for
patients with non-valvular atrial fibrillation who are at increased risk for stroke,...
Age: 18 years - 66+
Gender: All
Mobile Ostomates Resources for Patients and Caregivers
The scope of this research is to examine the acceptability and feasibility of a refined web-based intervention ("STOMA Care" app) by conducting a randomized pilot consisting of bladder and colorectal cancer patients scheduled for ostomy surgery at Mount Sinai Health Sys...
Age: 21 years - 66+
Gender: All
A Study of GLB-001 in Patients With Relapsed or Refractory Acute Myeloid Leukemia or Relapsed or Refractory Higher Risk Myelodysplastic Syndromes
Study GLB-001-01 is a first-in-human (FIH), Phase 1, open-label, dose escalation and
expansion clinical study of GLB-001 in participants with relapsed or refractory acute myeloid
leukemia (R/R AML) or in participants with relapsed or refractory higher-risk myelodysp...
Age: 18 years - 66+
Gender: All
INcreased Sun Exposure Without Pain In Research Participants With EPP or XLP
To investigate the efficacy of MT-7117 on time to onset and severity of first prodromal
symptoms (burning, tingling, itching, or stinging) associated with sunlight exposure in
adults and adolescents with EPP or XLP.
Age: 12 - 75 years
Gender: All
Psychopharmacological Treatment of Emotional Distress
This is an inpatient four-arm randomized control trial comparing single drug clonazepam (S arm), a two-drug combination clonazepam/olanzapine (D arm), and a three-drug combination clonazepam/olanzapine/buprenorphine (T arm) with treatment as usual (TAU arm) in the treat...
Age: 18 years - 66+
Gender: All